Open subtitles 2018 : Statistical rescoring of sentence alignments in large, noisy parallel corpora

Peer reviewe

Biological and chemical oceanographic measurements in Far Northern Great Barrier Reef - February 1990

This report presents and sununarises the results of biological and chemical oceanographic sampling carried out in the far northern Great Barrier Reef during February 1990. The region sampled (ca. 11-13°S), lies adjacent to the eastern side of Cape York Peninsula, locations on which are under consideration for national park declaration, the construction of a rocket launching facility and silica sand mining. As little is known regarding the biological and chemical oceanography of the region, a reconnaissance survey was carried out to obtain baseline data on hydrographic, nutrient and sediment characteristics of shelf waters and sediments. It is expected that the data presented herein will form part of the environmental assessment for development in, and conservation of, the region and serve as a basis for designing more detailed and focused water quality surveys

Fracturas del macizo trocantéreo. Estudio comparativo Ender-DHS: revision de 114 casos

Se presenta un estudio retrospectivo de 114 fracturas pertrocantéreas tratadas con enclavado elástico de Ender (71) y tornillo placa deslizante, DHS (43). Se efectuó un estudio estadístico descriptivo-comparativo entre los 2 grupos de pacientes según la técnica quirúrgica empleada. Se constató un mayor índice de estabilidad usando el DHS (81%), frente al 6 1 % del otro grupo. La tasa de complicaciones fue del 16% y 55% respectivamente. Los resultados clínicos fueron mejores en los enfermos tratados con DHS, fundamentalmente en cuanto a la deambulación que se consiguió en el 98% (Ender 75%), ausencia de dolor y movilidad conservada. Los autores piensan que la estabilidad preoperatoria no influye en la solidez del montaje usando el DHS, pero con la técnica de Ender ésta disminuye en las fracturas inestables; por ello, la técnica de Ender estaría solamente indicada en el tratamiento de fracturas estables en pacientes de edad avanzada o con mal estado general, aunque en clara competencia con el DHS.A retrospective study of 114 intertrochanteric fractures operated on either with Ender's rods (71) or dynamic hip screws, DHS (43) is presented. A statistical descriptive-comparative study between the 2 groups was attempted. There was a greater index of stability using the DHS (82%) than Ender's rods (61%). The rate of complications was 16% and 55% respectively. The clinical outcome was better in cases treated with DHS, specially for walking ability, which was regained in the 98% of cases (Ender 75%), painless and preserved mobility. The authors think that the stability before operation do not influence the solidity of the assembly using the DHS device. On the contrary, with the Ender's technique the fixation is no satisfactory in unstables fractures. Ender's rods would only be suitable for treatment of stable fractures in older patient or with serious associated diseases, although in clear competition with the DHS

Attachment-specific speech patterns induce dysphoric mood changes in the listener as a function of individual differences in attachment characteristics and psychopathology

Objectives Early childhood experiences influence cognitive-emotional development, with insecure attachment predisposing to potential psychopathologies. We investigated whether narratives containing attachment-specific speech patterns shape listeners’ emotional responses and social intentions. Design First, 149 healthy participants listened to three narratives characteristic for secure, insecure-preoccupied, and insecure-dismissing attachment. Following each narrative, the wellbeing and interpersonal reactivity as a particular aspect of emotional reactivity of the listener were assessed. Likewise, psychopathological aspects of personality were evaluated. A follow-up study compared 10 psychosomatic patients with a current depressive episode and/or personality disorder with distinct depressive symptoms and 10 age- and gender-matched healthy controls. Methods Effects of narratives on listeners’ mental state were tested with repeated-measures AN(C)OVA. Mediating effects in the listener (attachment characteristics in the context of personality traits) were explored. Narrative effects were compared between patients and controls. Results Listening to insecure attachment narratives reduced wellbeing in controls. Nevertheless, tendency for social interaction was highest following the insecure-preoccupied narrative. Importantly, listeners’ individual attachment characteristics mediated the relationship between wellbeing/interpersonal reactivity following the insecure-preoccupied narrative and levels of psychopathology. Furthermore, compared with healthy participants, patients showed higher emotional reactivity following exposure to the insecure-preoccupied narrative, represented by lower wellbeing and lower estimation of friendliness towards the narrator. Conclusions Exposure to attachment-specific speech patterns can result in dysphoric mood changes. Specifically, the insecure-preoccupied narrative influenced the listeners’ emotional state, which was further mediated by the individual attachment patterns and psychopathological personality characteristics. This deepens the understanding of interpersonal processes, especially in psychotherapeutic settings

Dysregulated Proinflammatory and Fibrogenic Phenotype of Fibroblasts in Cystic Fibrosis

Morbi-mortality in cystic fibrosis (CF) is mainly related to chronic lung infection and inflammation, uncontrolled tissue rearrangements and fibrosis, and yet the underlying mechanisms remain largely unknown. We evaluated inflammatory and fibrosis responses to bleomycin in F508del homozygous and wild-type mice, and phenotype of fibroblasts explanted from mouse lungs and skin. The effect of vardenafil, a cGMP-specific phosphodiesterase type 5 inhibitor, was tested in vivo and in culture. Responses of proinflammatory and fibrotic markers to bleomycin were enhanced in lungs and skin of CF mice and were prevented by treatment with vardenafil. Purified lung and skin fibroblasts from CF mice proliferated and differentiated into myofibroblasts more prominently and displayed higher sensitivity to growth factors than those recovered from wild-type littermates. Under inflammatory stimulation, mRNA and protein expression of proinflammatory mediators were higher in CF than in wild-type fibroblasts, in which CFTR expression reached similar levels to those observed in other non-epithelial cells, such as macrophages. Increased proinflammatory responses in CF fibroblasts were reduced by half with submicromolar concentrations of vardenafil. Proinflammatory and fibrogenic functions of fibroblasts are upregulated in CF and are reduced by vardenafil. This study provides compelling new support for targeting cGMP signaling pathway in CF pharmacotherapy

The European Registered Toxicologist (ERT) : Current status and prospects for advancement

Acknowledgements We would like to thank the participants of the five workshops in which the issues presented in this paper were discussed and the revised guidelines prepared, as well as the EUROTOX Executive Committee and the societies of toxicology of Sweden, the Netherlands, Switzerland, Austria and France for their support which allowed the workshops to take place.Peer reviewedPostprin

Opto-mechanical measurement of micro-trap via nonlinear cavity enhanced Raman scattering spectrum

High-gain resonant nonlinear Raman scattering on trapped cold atoms within a high-fineness ring optical cavity is simply explained under a nonlinear opto-mechanical mechanism, and a proposal using it to detect frequency of micro-trap on atom chip is presented. The enhancement of scattering spectrum is due to a coherent Raman conversion between two different cavity modes mediated by collective vibrations of atoms through nonlinear opto-mechanical couplings. The physical conditions of this technique are roughly estimated on Rubidium atoms, and a simple quantum analysis as well as a multi-body semiclassical simulation on this nonlinear Raman process is conducted.Comment: 7 pages, 2 figure